2025 Poster Presentations
P152: ANALYSIS OF SURVIVAL AND PREDICTION OF RECURRENCE OF ATYPICAL AND ANAPLASTIC MENINGIOMAS BASED ON TUMOR LOCATION
Peter Erickson, BA; Rafael Martinez-Perez; Geisinger Medical Center
Purpose: World Health Organization (WHO) Grade 2 and 3 meningiomas have high rates of recurrence. However, ambiguity remains on the role of radiation therapy as an adjunct to surgery for treatment. In this study, we aim to characterize the longitudinal impact of radiation therapy on progression free survival (PFS) and overall survival (OS) based on several variables including tumor size, location, and type of radiation. In addition we aim to determine wether tumor location (skull base) has significant impact on survival and/or recurrence.
Methods and Materials: Data were collected through retroactive chart reviews for patients with pathologically diagnosed Meningioma who underwent surgical resection with or without radiation therapy between the age of 18 and 100. Progression free survival (PFS) and overall survival (OS) were then calculated. Analysis on tumor location for predictors of PFS was performed. We intend to continue data collection to evaluate response to radiation therapy for tumor size and the type/amount of radiation received. SPSS v 22.0 was used for statistical analysis of Kaplan Meier curves and p < .05 was the threshold for statistical significance.
Results: 25 patients were included in the study from a selected retrospective case series of patients undergoing surgery for meningioma 1,300. 22 (88 %) of the patients had WHO grade II meningiomas and 3 (12%) of the patients had WHO grade III meningiomas. 13 (52%) of the patients were female, while 12 (48%) of the patients were male. Skull based accounted for 4 (16%) of the cranial meningiomas, while 21 (84%) of the meningiomas were convexity. Among the skull based patients, 3 (75%) received radiation therapy in addition to surgical excision. 11 of the convexity based meningioma patients received radiation (52%). No significant differences were found amongst the proportioon of patients with SBM who underwent radiation in comparison to those with Convexity Meningiomas. PFS was significantly shorter for patients with skull base meningiomas compared to convexity (p =0.13, Log rank).
Conclusion: For patients with grade II or III meningiomas, location (skull base) predicts earlier recurrence, while larger series of patients are needed to determine wether this have an impact on survival. Based on these findings, long term follow up with shorter interval MRI is recommended for patients harboring skull base meningiomas.