2026 Proffered Presentations
S154: SINONASAL GLOMANGIOPERICTYOMA: A LARGE MULTI-SITE RETROSPECTIVE COHORT REVIEW
Kareem Al-Mulki, MD; Anna Davide; Ruth Agwaze; Jacob Eide, MD; Janalee Stokken; Erin O'Brien; Mayo Clinic
Background: Sinonasal glomangioperictyoma is a rare neoplasm, accounting for only 0.5% of all nasal cavity masses. It is thought to have low malignant risk but have the potential for local recurrence. Given its rarity, literature is limited to small case series of only a few patients. This study seeks to better characterize this disease entity by presenting one of the largest single study retrospective cohorts on sinonasal glomangioperictyoma.
Methods: A multi-site retrospective chart review was conducted on patients with pathology report findings of sinonasal glomangiopericytoma. Data regarding demographics, comorbidities, tumor location, and treatment were systematically collected.
Results: 19 patients with sinonasal glomangioperictyoma were identified. Seven were female and 12 were male. The average age of presentation was 67 ± 11 years. The most common presenting symptom was nasal drainage (anteriorly or posteriorly), followed by nasal obstruction and epistaxis. Six patients had concurrent chronic sinusitis either with or without polyps, only one had a history of prior sinus surgery. The most common comorbidity was hypertension in 16 patients. The most common location in 12 patients was along the posterior-superior septum extending to the olfactory cleft. The second most common location was along the anterior-superior septum (four patients). One tumor was located on the middle turbinate and one was in the sphenoid sinus. 17 of 19 patients underwent endoscopic surgical resection, none of which underwent pre-operative embolization of tumor. One patient was lost to follow up and one patient had their tumor biopsied without definitive resection. Of the 17 patients who underwent surgery, 15 had negative final margins post-operatively. Two had positive margins and are being observed for tumor growth. Intraoperative CSF leak was encountered in only one patient and repaired. In the patients with negative margins, there were no recurrences in any patient with an average length of follow up of 19 months (range 1-61 months). The two patients with positive margins have not demonstrated gross tumor recurrence.
Conclusion: This represents one of the largest clinical retrospective cohort studies of sinonasal glomangiopericytoma ever performed. Notable findings include the most common location being in the nasal cavity (95%), rather than within a sinus. With a mean follow up of 19 months (range 1-61 months), no patient resected to negative margins exhibited recurrence. Of the patients with positive margins, none exhibited dramatic tumor growth. Further studies should be performed to better characterize treatment algorithms, including the extent of resection that should be performed.