2026 Poster Presentations
P307: HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA: CASE SERIES AT A SINGLE INSTITUTION
Molly M Murray, MD; Kareem M Al-Mulki; Jacob G Eide, MD; Mayo Clinic
Background: Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a relatively new, distinct pathologic entity with only about 100 cases published worldwide. While most sinonasal malignancies present with high T-stage disease and have high rates of recurrence and mortality at five years, HPV-related multiphenotypic sinonasal carcinoma appears to behave more favorably.
Aim: We aim to review all cases of HPV-related multiphenotypic sinonasal carcinoma that have been treated at a single tertiary care academic institution to add to the small number of reported cases in the literature.
Methods: We performed a retrospective chart review of all patients who underwent surgical resection for HPV-related sinonasal carcinoma at a single institution from 2018 onward. Data collection included demographic information, diagnostic data, T-staging, treatment strategy, surgical details, pathologic data, and follow up information. Data was analyzed with descriptive statistics.
Results: We identified nine patients. The median age was 69 years old (range 55-91), and eight patients were male. Two patients presented with a T1 tumor, three presented with a T2 tumor, three presented with a T3 tumor, and one presented with a T4b tumor. All patients underwent endoscopic surgical resection. The tumor attachment sites were the septum (n=3), inferior turbinate (n=2), middle turbinate (n=1), nasal floor (n=1), and cribiform skull base (n=1). Following surgical resection, margins were negative in seven of nine patients. In one case, no residual tumor was seen after neoadjuvant radiation therapy. Five patients received radiation therapy (RT); four adjuvant, one neoadjuvant. Only one patient received chemotherapy. Median clinical follow up was 19 months (range 5-70 months). Six out of nine patients had at least one year of follow up. No patients had evidence of recurrence during their follow up period. There were no mortalities during the follow up period.
Conclusion: We present nine cases of HPV-related multiphenotypic sinonasal carcinoma. Our experience supports the small, but growing body of literature that suggests this pathologic diagnosis has more favorable outcomes than other sinonasal malignancies.