2026 Poster Presentations
P302: RECURRENCE IS NOT ASSOCIATED WITH A REDUCED QUALITY OF LIFE IN PATIENTS WITH RECURRENT SINONASAL MALIGNANCY
Jason R Crossley, MD1; Abigail R Cartus1; Daniel M Beswick, MD2; Peter H Hwang, MD3; Garret Choby, MD1; Edward C Kuan, MD4; Nithin D Adappa, MD5; Mathew Geltzeiler, MD6; Anne E Getz, MD7; Ian M Humphries, DO8; Christopher H Le, MD9; Waleed M Abuzeid, MD8; Eugene H Chang, MD9; Aria Jafari, MD8; Todd T Kingdom, MD7; Michael A Kohanski, MD5; Jivianne K Lee, MD2; Jayakar V Nayak, MD3; Zara M Patel, MD3; Carlos D Pinheiro-Neto, MD10; Adam C Resnick, PhD5; Timothy L Smith, MD6; Carl H Snyderman, MD1; Maie A St. John, MD2; Jay Storm, MD5; Eric W Wang, MD1; 1University of Pittsburgh; 2UCLA; 3Stanford University; 4UCI; 5University of Pennsylvania; 6OHSU; 7University of Colorado; 8University of Washington; 9University of Arizona; 10Mayo Clinic
Introduction: Sinonasal cancer represents a heterogenous group of malignancies which as a group have poor survival. Recent work demonstrates that patients with sinonasal malignancy have lower quality of life prior to treatment (QoL). Patients with other solid tumors have been found to have lower QoL on recurrence than initial diagnosis, driven primarily by lower scores in physical domains. No studies to date have investigated the impact of recurrent sinonasal cancer on QoL.
Methods: A prospective, observational, multicenter, hypothesis-driven study design was used. Our first hypothesis was that patients with recurrent sinonasal cancer have worse physical QoL than patients with non-recurrent sinonasal cancer. The second hypothesis was that patients with recurrent sinonasal cancer have better psychological QoL than patients with non-recurrent sinonasal cancer. Physical subdomains of the University of Washington QoL Questionnaire were used to quantify physical QoL. The “frustrated” subdomain of the Sinonasal Outcome Tests-22 was used to measure psychological QoL. Demographics, comorbidities, tumor histology, disease extent, and treatment modalities were collected. Mixed effects modeling was used to compare QoL outcomes of interest between patients with recurrent and those without recurrent sinonasal cancer. QoL outcomes were adjusted for covariates previously observed to impact QoL in sinonasal cancer patients, including orbital involvement, skull base erosion, perineural invasion, and treatment with neck dissection. Time of QoL survey completion was categorized from initial or recurrent diagnosis to 6 months, 7-12 months, 13-18 months, 19-24 months, and greater than 24 months. Patients who participated in the CORSICA study from 2015 to 2024 were included.
Results: 675 patients were included. Mean age was 64 years and 52% of patients were male. 84 patients had history of recurrence at the time of data extraction. Race, smoking history, education level and T-stage were similar between recurrent and non-recurrent groups. While melanoma was higher percentage in the recurrent group (27.1% versus 12.3%), other histopathologies had similar rates of recurrence. An average of 3.6 surveys were completed per patient. Unadjusted and adjusted mixed modeling of physical QoL measures demonstrated no significant difference within any follow up interval. There was a trend towards lower physical quality of life among patients recurrence relative to patients with initial diagnosis during the 7-12 month interval in both unadjusted and adjusted mixed models, however this difference was not statistically significant (p = 0.706). Psychological QoL measures were similar in unadjusted and adjusted mixed models. There was a trend towards decreased psychological QoL in recurrent patients in the 13-18 month interval after diagnosis however this difference was not statistically significant (p = 0.351).
Conclusion: Patients with sinonasal cancers appear to have unique QoL trajectories among patients with recurrent solid tumors in that both physical and psychological QoL do not appear to be different in the recurrent versus initial diagnosis setting. This suggests that symptomatology and impact of QoL may not be distinguishing features of recurrence in SNM, promoting the concept of continual radiographic and endoscopic surveillance.