2026 Poster Presentations
P201: DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF PATIENTS WITH PITUITARY TUMORS: A 10-YEAR RETROSPECTIVE OBSERVATIONAL ANALYSIS AT A REFERRAL CENTER IN WESTERN MEXICO.
Santiago Nunez-Velasco, MD; Gabriel Gómez-Zamora, MD; Andrea P Ramos-Mora, MD; Estefania Ramirez-Medina, MD; Arturo J Navarro-Gómez, MD; Enrique Velarde-Martinez, MD; Jose J Jauregui-Gamboa, MD; Neurosurgery Department Hospital Civil de Guadalajara
Introduction: Pituitary tumors are the most common neoplasm of the sellar region and represent a clinical challenge. Their heterogeneity ranges from microadenomas to aggressive macroadenomas capable of compromising adjacent structures and disrupting hormonal balance. They are classified as functioning and non-functioning tumors, along with tumor size, it determines clinical presentation, therapeutic decisions, and prognosis.
Objective: Analyze the clinical, demographic, and radiological characteristics of patients undergoing endoscopic transsphenoidal surgery for pituitary adenomas between 2014-2025 at a referral center in Mexico.
Methods: We reviewed the medical records of all patients diagnosed with pituitary adenomas between 2014-2025 (excluding 2020 due to pandemic), collecting demographic information and characterizing tumors according to size, sellar and suprasellar extension, hormonal activity, and the specific type of hormone secreted.
Results: A total of 324 patients were included, with a mean age of 45.9 years; 182 (56%) were women and 142 (44%) men. Regarding tumor characteristics, 293 (90%) were classified as macroadenomas, 21 (6%) as microadenomas, and in 10 cases (3.1%) size information was unavailable. Sellar and suprasellar invasion was evaluated using the Hardy classification. Cavernous sinus invasion was assessed using the Knosp classification. Regarding hormonal functionality, 211 (65%) had non-functioning and 112 (34.5%) functioning.
Conclusions: The results from this center reflects the challenging nature of the cases treated and underscore the importance of the institution as a high-specialty center, recognized for its expertise in managing pituitary tumors through advanced surgical approaches and multidisciplinary strategies.
| Characteristic | Value (n%) |
| Microadenomas | 21 (6) |
| Macroadenomas | 293 (90) |
| Sellar Extension - Hardy Classification | |
| I | 20 (6.1) |
| II | 84 (25.8) |
| III | 89 (27.4) |
| IV | 103 (31.7) |
| Data missing | 25 (8) |
| Suprasellar Extension - Hardy Classification | |
| A | 91 (28) |
| B | 47 (14.5) |
| C | 88 (27.1) |
| D | 47 (14.5) |
| E | 25 (7.7) |
| Data missing | 26 (8) |
| Cavernous Sinus Invasion - Knosp Classification | |
| 0 | 15 (4.63) |
| 1 | 51 (15.7) |
| 2 | 72 (22.2) |
| 3 | 62 (19.1) |
| 4 | 99 (30.5) |
| Missing Data | 25 (7.7) |
| Tumoral Hormone Production | Value (n%) |
| Functioning | 112 (34.5) |
| Prolactine | 29 (25.8) |
| Adrenocorticotropic Hormone | 25 (22.3) |
| Growing Hormone | 19 (16.9) |
| Thyroid-Stimulanting Hormone | 1 (0.8) |
| Non-Functioning | 221 (65.1) |
| Data Missing | 2 (0.6) |